Professor Ranganath Rao, an archaeological researcher, visits a library in Greece and learns that Lord Krishna has trusted Udhava to safeguard his anklet which is equipped with solutions to problems faced by humans in Kali Yugam. Karthikeya is a doctor from Hyderabad who believes in science and logic. To fulfil a vow made by his mother years ago, Karthikeya leaves for Dwaraka along with his mother and uncle Sadananda, who is a devotee of Lord Krishna. One night, a wounded Rao meets Karthikeya to reveal something but is kidnapped before Karthikeya could treat him. The following day, his mother goes missing and Karthikeya is arrested by the police who accuse him of murder. The police ask Karthikeya about the information which Rao allegedly told him in order to let go.

A woman rescues Karthikeya from the police, where she introduces herself as Rao's granddaughter Mugdha. Meanwhile, a mysterious man attacks Karthikeya to kill him but stops when he sees the idol of Lord Krishna. They learn through a sage that man is Abheera, a member of an exiled cult that worships Lord Krishna. Their aim is to kill anyone who approaches Krishna's belongings. Later, Karthikeya finds his mother and allows her to participate in the 11 days of Bhajan of Krishna, so that he can unfold the mystery. They visit Rao's office in Bet Dwarka and read a letter written by him. Rao has found that Udhava had hidden the anklet in an unknown location, leaving clues to find it. For centuries, many adventurous men tried to find it in vain. Pallava King Suryavarman reached the closest and told the penultimate clue to Greek traveller Ptolemy.

Ptolemy hid the object with the clue in Krishna Thatakam which Karthikeya retrieves. It is revealed that another professor named Santanu, who is also after the anklet, had killed Rao and notified the cops about Karthikeya. Santanu declares a reward for those who find Karthikeya and Mugdha. However, they decode the peacock-shaped object, locate the final clue in Govardhana Hill and hire Suleman's truck to smuggle them to that place. Upon arrival, they are captured by villagers for the reward but they manage to escape. They enter the hill with the help of the peacock-shaped object and retrieve a telescope from inside. The following morning, Mugdha escapes with the telescope while Karthikeya and others are captured by Santanu's men who leave them to die in the desert.

Mugdha returns and rescues them, also finding the contact of Dr. Dhanvanthri, who might help them. They travel to Himachal Pradesh and visit him. Dhanvanthri explains that Rao and Santanu were part of a secret society that believes ancient India has technology far more advanced than the modern world. When Santanu proposed to use Krishna's anklet for selfish reasons, Rao sought to use it for collective good instead. Fate let Rao choose Karthikeya to carry forward his mission. Dhanvanthri also explains that Krishna was not just a god, but also a person born and brought up on this planet who excelled in various fields. While returning, they are surrounded by the police but they escape through a frozen river.